A member asked:

Is there a specific binding site just for alcohol on the gaba receptor just like there's a specific benzodiazepine binding site?

8 doctors weighed in across 4 answers

Gaba receptor: Great question! alcohol is known to bind to GABA receptors. We know that pharmacologic inhibition of these receptors using drugs such as Campral and Baclofen can reduce the incidence of relapse drinking and binge drinking. Thus, these drugs, along with naltexone (vivitrol- which acts on the mu receptor) are excellent choices for use in chronic alcoholism.

Answered 2/18/2015

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No, they both do.: Both etoh and benzo's bind to the same GABA receptors in the brain.

Answered 2/18/2015

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No: There is no specific receptor for ethanol, just as there is no single GABA receptor.

Answered 2/18/2015

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Complicated!: Specific gabaa receptor subtypes are sensitive at lower doses (social drinking) while other subtypes respond to ethanol at doses attained by severe intoxication. Furthermore, it increases gabaergic neurotransmission through indirect effects, including the elevation of endogenous gabaergic neuroactive steroids, presynaptic release of gaba, and dephosphorylation of gabaa receptors.

Answered 5/7/2016

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