A member asked:

I'm on methotrexate tablets for sle , my dentist wants medical release from my rheumatologist , why? what is the dangerous effects of methotrexate ?

3 doctors weighed in across 2 answers

Safety: Methotrexate has some rather significant warnings that cannot be ignored. Your dentist is trying to keep you safe. Some bad reactions have been reported when used with nonsteroidal antiinflammatories like ibuprophen. Your rheumatologist should be aware of what your dentist may recommend to avoid complications.

Answered 6/28/2014

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Side effects: Methotrexate is a very powerful drug to treat mostly cancer and a few other conditions. Side effects of Methotrexate could be fatal. These range from mucosal damage to liver and kidney damage and lymphoma. It also depresses the immune system making you much more susceptible to infection. Your dentist is practicing good dentistry by having you released by your md to his care. He is having your back.

Answered 10/3/2015

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