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A 51-year-old male asked:

Methotrexate :the most common adverse effects include: hepatotoxicity (liver damage),but could this be seen in low dose for lupus affecting skin ?

1 doctor answer1 doctor weighed in
Dr. J. Lawrence Dohan
Dermatology 58 years experience
Yes: Toxicity to liver, kidney, intestine, bone marrow, etc., is related to dosing and duration of exposure. Must not drink alcohol. Dosed once a week. Daily folic acid reduces toxicity. Various treatments exist for discoid lupus. Protect from sun.
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Last updated Mar 22, 2020

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