Ct shows slightly enlarged mediastinal node. what is best way to rule out malignancy. stage 2b bc diagnosis 4/13. calcifications on thyroid. cysts on liver?

Further investigatio: By pet scan if positive , mediastinoscopy and biopsy of the node.

Pet/ct, biopsy: See my answer to the similar topic. You can start with a noninvasive pet/ct to see if there is any increased metabolic uptake in the lymph nodes. If by size criteria the size of the mediastinal lymph nodes are large enough and worrisome, you can get a image guided biopsy of the lymph nodes. Tumor markers may also help if you had elevated tumor markers to start off with.

See Endo and Oncolog: You report calcifications in the thyroid. This should be evaluated by and endocrinologist. If small (micro) calcifications it is more concerning and given h/o breast cancer should be evaluated by your oncologist to make sure not a recurrence. Imaging can help and depending on site of lymph node biopsy might be possible for more definitive answer.

Need more info: Is there an older chest ct to compare the mediastinal ln to? That node is what I am most worried about. Pet/ct may help, especially if that node is bigger than 1 cm. Thyroid nodule should be evaluated with neck ultrasound and could be biopsied, but is not likely breast cancer metastasis. Liver cyst, assuming correct interpretation, is a benign finding and can be followed.