Endocytosis: Entry of a virus into a cell is by endocytic vesicles transporting the incoming viral particles from the plasma membrane to the perinuclear area of the host cell, where conditions for viral replication are optimal. Cell damage seldom occurs prior to replication and so it is unlikely that the inflammatory process will create pain, even on a neuronal cell, bur doubt there is any way to prove this.
Answered 8/13/2013
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