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Alameda, CA
A 58-year-old female asked:

With a diagnosis of depression and ptsd and negativefindings on mri and ct scan, could there be any other organic cause for impaired memory, mild confusion, and slow speech and word finding that does not show up onmri?

3 doctor answers6 doctors weighed in
Dr. Alvin Lin
Geriatrics 30 years experience
Many possibilities: 1st, MRI & ct only demonstrate anatomy & structure; they don't assess function. You need f-mri (functional mri), ct perfusion, pet etc to show abnormal function as described. However this doesn't explain why, like traumatic brain injury eg concussion or knockout. Ask doc (neurologist of geriatrician) for dementia evaluation. Unfortunately, while we look for reversible causes, often doesn't respond.
Dr. Alvin Lin
Dr. Alvin Lin commented
Geriatrics 30 years experience
Provided original answer
By "reversible causes", I'm referring to those lab tests that we run looking for anemia, liver/kidney disease, B12 deficiency, syphilis, etc. However, as Dr. Alves noted, depression & PTSD need to be addressed 1st as these are reversible/treatable and can result in resolution of above noted symptoms.
Aug 2, 2013
Dr. Donald Alves
Emergency Medicine 24 years experience
Not likely: Need to treat your depression and ptsd first so they do not cloud your thinking or your evaluation / testing if remain after feeling back to baseline. Good luck.
Dr. Bennett Machanic
Neurology 52 years experience
Yes, many: Thyroid problems, pernicious anemia, infection with HIV or syphilis, alcohol and nutritional issues, medication reactions, use of recreational drugs, and many others. Sounds like your issues need to be sorted out, and simplest and direct way is to have neuro-psychological testing.

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Last updated Sep 1, 2014

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