Difference between fordyce spots and lip cancer for upper lip?

Big difference: Fordyce spots (or granules) are natural findings in the oral cavity. Lip cancer looks vastly different. Your oral surgeon should have a look.

Fordyce vs Cancer: Fordyce granules or spots are ectopic sebaceous glands and a "variation of normal". A lip malignancy - carcinoma, is abnormal and its clinical cause, presentation, and treatment are drastically different. If Fordyce major cosmetic concern for you, co2 laser treatment may reduce appearance.