Restless legs, constant crying, muscle twitching, wakes up a lot @nite, constant worry on health, tingling, can't focus, very tense upper back/neck muscle is this anxiety? wifes symptoms, can't help her :(

See a doctor: Whether or not this is restless leg syndrome will require a full medical assessment. If it is, then there are therapeutic options which can be tried. This is a situation in which an experienced clinician doing a full evaluation can make a powerful difference in your wife's health and comfort. Good luck.

I would: Suggest she seeks out counciling for all her stress. Psychological help will help her constant worry.

Need psych evaluatio: You are describing elements of depression (crying spells, sleep disturbance and inability to concentrate). Need full psychiatric evaluation to rule out medical disorders as cause and treatment asap.