Confused; after an ischemic stroke, been prescribed 325 mg aspirin and plavix (clopidogrel). research doesn't support this; doctor says it's okay. pls advise.

Stroke: The combination of Aspirin and Plavix (clopidogrel) has not been shown to offer any additional benefit in reducing the risk of stroke when compared to either one alone. The only gain is an increased risk of bleeding complications. Still, its combination can be used in recent coronary or other arterial stent placement and atrial fibrillation patients when anticoagulation is not a feasible option (anticoagulation is still preferred option in atrial fibrillation treatment).

Discuss with your MD: There are several ways to prevent stroke. Anticoagulation is key but how to do it varies. Research has not supported the use of this combination in the past but a very recent study in the new england journal of medicine (n engl j med. 2013 jun 26) provides evidence to the contrary for some. It all comes down to having an honest discussion wiht your doctor as criteria vary by patient.