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A 48-year-old member asked:

Can you please tell me genetics of sickle cell anemia?

2 doctor answers5 doctors weighed in
Dr. Charles Sturgis
Pathology 29 years experience
Inherited disease.: Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic.
Dr. Michael Engel
Pediatric Hematology and Oncology 20 years experience
Sickle cell disease: Occurs when both copies of their beta globin gene (one received from each parent) harbor a mutation in codon 6 that changes the encoded Amino Acid from glutamate to valine. Patients can't make normal hemoglobin consequently, and instead can only make hgbs. If you inherit one normal and one beta-s, you can make some normal (hgba) and some hgbs. The normal hgba limits sickling. This is sickle trait.

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A 48-year-old member asked:

Could you tell me what gene is affected by sickle cell anemia?

2 doctor answers5 doctors weighed in
Dr. Joseph Torkildson
Pediatric Hematology and Oncology 39 years experience
The beta globin gene: Hemoglobin is a complicated molecule in red blood cells that carries oxygen from the lungs to the rest of the body. It contains 4 protein chains, 2 Alpha chains and 2 beta chains. Sickle cell disease is caused by specific mutation in the beta globin gene. We each have two beta globin genes. If one has the s mutation you have sickle trait; if both have the s mutation you have sickle cell anemia.
A 49-year-old member asked:

Can you tell me how is sickle cell anemia passed down?

1 doctor answer1 doctor weighed in
Dr. Aniket Saha
Pediatrics - Hematology & Oncology 14 years experience
Genetic: Sickle cell disease is a genetic condition. You get one set of genes from each of your parents. If they both carry the gene, it is possible for them to pass it to their child. If both parents pass the affected gene, then the child will have sickle cell disease. If one parent passes it to the child, then the child will be a carrier but not be affected by sickle cell disease.
A 40-year-old member asked:

Please tell me the cause of sickle cell anemia?

2 doctor answers5 doctors weighed in
Dr. James Ball
Pediatric Hematology and Oncology 19 years experience
Stiffened hemoglobin: There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms.
A 39-year-old member asked:

What to tell me about sickle cell anemia?

1 doctor answer2 doctors weighed in
Dr. Steven Ginsberg
Internal Medicine - Hematology & Oncology 37 years experience
See below: Sickle cell anemia occurs when 2 abnormal hemoglobin genes are present and a person's body produces sickle cell hemoglobin exclusively. 1 sickle cell gene and a normal gene produce sickle trait, which has no symptoms. Other abnormal hemoglobin genes can combine with a sickle cell gene and produce other types of anemia. There are several other genetic hemoglobin abnormalities.

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Last updated Jun 24, 2014
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