A 18-year-old female asked:
hiya, what are the causes of sickle cell anemia? i know it is inherited but i need it explained in a way that can tell me the causes of gene mutation.
2 doctor answers
Dr. Michael Gabor answered
32 years experience Diagnostic Radiology
Gene mutations: are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection.
Answered on May 28, 2017
Dr. James Ferguson answered
45 years experience Pediatrics
2 doses of gene: SSA occurs when the baby gets a sickle gene from both parents.This gene causes the cell to deform (sickle) in some conditions in the body.These cells break down easier resulting in anemia.If they only get 1 sickle gene the good 2nd gene keeps it from deforming.The mutation was random and occurred 10's of thousands of years ago. Being a carrier of one gene makes you less likely to die from malaria
Answered on May 29, 2017
People also searched for:
I have a fungi on my tongue what are the causes for that how can i get rid of it i use sodium bicarbonate to wash it
Ut feels like i got a bubble in the topper right of my chest near my neck and when i strech it hurts and some times when i wake up i am short of breath and feel like am ill but goes with in 2min please tell me what it is and what 2 do
Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute!