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A 39-year-old member asked:

Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

2 doctor answers4 doctors weighed in
Dr. Steven Ginsberg
Internal Medicine - Hematology & Oncology 38 years experience
Both carriers and : People with the disease are protected (not immune). People with trait historically were more likely to survive into adulthood to pass along the sickle cell gene. People with ss hemglobin, until recently, were not likely to survive into adulthood to have children.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Heidi Fowler
Psychiatry 26 years experience
Sickle Cell /Malaria: In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.”
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Heidi Fowler
Psychiatry 26 years experience
Provided original answer
http://www.cdc.gov/malaria/about/biology/sickle_cell.html ** This is not the case for a person with sickle-cell disease. People who are Sickle Cell carriers are not immune to Malaria because they can still become infected. But it may improve survivability in Malarial areas.
Oct 13, 2014

Similar questions

A 45-year-old member asked:

Why is it that carriers of sickle cell anemia are immune to malaria?

2 doctor answers4 doctors weighed in
Dr. James Ball
Pediatric Hematology and Oncology 20 years experience
Malaria infects RBCs: Malaria infects red blood cells. Persons with sickle cell trait will often be "immune" because the malaria infection is not allowed to propagate through the rbcs because the sickle trait causes them to die a little faster when infected. Persons with sickle cell disease get very sick with malaria, because of sickle cell related complications. Persons with normal hemoglobin gets sick from malaria.
Created for people with ongoing healthcare needs but benefits everyone.
A 37-year-old member asked:

I'm wondering why are carriers for sickle cell anemia resistant to malaria?

4 doctor answers11 doctors weighed in
Dr. Liawaty Ho
Hematology and Oncology 24 years experience
Sickle and malaria: Patients with sickle cell disease are protected against severe and complicated malaria infection- by 2 mechanism: -1. Cells infected with malaria parasites had accelerated sickling compared with non-infected cells- and as the result the cell would be destroyed/ promoting removal of infected cells from the circulation `2.Impaired parasite growth due to reduce o2 content in sickle cell.
Created for people with ongoing healthcare needs but benefits everyone.
A 40-year-old member asked:

Please tell me the cause of sickle cell anemia?

2 doctor answers5 doctors weighed in
Dr. James Ball
Pediatric Hematology and Oncology 20 years experience
Stiffened hemoglobin: There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Oct 31, 2014
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