A member asked:

My doctor prefers pravastatin 80mg over lipitor (atorvastatin) 20mg or simvastatin 40mg. says it is safer but can't really tell me why. anyone agree and if so, why?

13 doctors weighed in across 2 answers

Drug interactions: Pravastatin is metabolized differently than Lipitor (atorvastatin) or simvastatin. It may reduce the risk of adverse effects caused by interactions with other medications metabolized in the liver. (lovastatin, simvastatin, or Atorvastatin are oxidized by cytochrome p450 3a4 [cyp3a4], which is inhibited by many drugs. Pravastatin or fluvastatin are not oxidized by cyp3a4).

Answered 2/28/2018

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Dr. Christopher White answered

Specializes in Cardiology

Lots of choice: Find a physician that will explain things to you.

Answered 4/22/2018

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How does simvastatin compare to lipitor (atorvastatin)?

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