What would be the least painful way to do a breast biopsy?

Most ways should be : This depends alot on your doctor and his/her experience doing biospies, but also on a patient's own tolerance for procedures and pain. No breast biopsy done while a patient is awake should be without local anesthesia. Your doctor shouold use plenty of local anesthetic in the skin as well as in the tissue inside the breast after your skin is prepped. After that, most types of biopsies are similar.

Breast biopsy pain: The type of biopsy you will have depends primarily on how the abnormality was found. In general, biopsies of the breast should not be very painful when performed capably with ample local anesthetic. The degree to which women feel a bruising/achy sensation afterward, though, can vary, depending on the needle size, number of samples, and vascularity of their tissue.

Needle biopsies: are performed under local anesthesia. According to a recent study in the Journal of the American College of Radiology, 40% of women reported no pain, and 49% reported mild pain.