A 25-year-old male asked:
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How is cyproheptadine and an SSRI safe to use together? Don't they both affect the serotonin transmitter? But often prescribed together by docs. Thx

1 doctor answer
Dr. Erik Messamore
23 years experience in Psychiatry
Serotonin antagonist: Cyproheptadine blocks receptors for serotonin, histamine, and acetylcholine. In my experience it is THE BEST treatment for akathisia. There are a handful of very old small studies suggesting antidepressant benefit. But it may worsen anxiety in some patients. It has been suggested as a way to block SSRI-induced sexual side effects. I almost never meet anyone whose doc prescribes it w/ SSRI meds.
Answered on Feb 26, 2015

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Serotonin syndrome: google is your friend: http://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/basics/definition/con-20028946
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