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A 19-year-old male asked:

how is cyproheptadine and an ssri safe to use together? don't they both affect the serotonin transmitter? but often prescribed together by docs. thx

1 doctor answer1 doctor weighed in
Dr. Erik Messamore
Psychiatry 24 years experience
Serotonin antagonist: Cyproheptadine blocks receptors for serotonin, histamine, and acetylcholine. In my experience it is THE BEST treatment for akathisia. There are a handful of very old small studies suggesting antidepressant benefit. But it may worsen anxiety in some patients. It has been suggested as a way to block SSRI-induced sexual side effects. I almost never meet anyone whose doc prescribes it w/ SSRI meds.

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Similar questions

A 31-year-old member asked:

Can you really take appetite suppressants with ssris?

2 doctor answers4 doctors weighed in
Dr. Stuart Wasser
Addiction Medicine 35 years experience
Yes: However any ssri has a potential to cause weight gain, wellbutrin (bupropion) or viiibryd may be better alternatives for people who are focused in keeping weight off.
A 34-year-old member asked:

Is there a safe and effective way to decrease and end the use of ssri's?

3 doctor answers13 doctors weighed in
Dr. Robert Kwok
Pediatrics 33 years experience
Follow Dr's guidance: A person wishing to stop an ssri can ask his doctor how to get off the medication. The doctor can help the patient decide if he is ready to stop the ssri, if he needs to stay on, or if he can switch to a non-ssri. If stopping, the doctor can give instructions on how to wean down the dose, if weaning is necessary.
A 24-year-old member asked:

Why is there a lot of negativity towards ssri's compared with other medications?

3 doctor answers16 doctors weighed in
Dr. James Cunnar
Family Medicine 27 years experience
Media/self-image: I believe that there was a lot of negative press a few years ago, when certain celebrities aggressively campaigned against their use (remember the post-partum depression rant?). There is also a negative correlation for the patient - that they can't fix their problem on their own.
Dr. Donald Hazlett
Psychiatry 54 years experience
This has been especially true in adoloscent patients and their families, and in the few years since the bad press, there has been an increase in adolscent suicide rates due to reluctance, I believe, on the part of Physicians and families to use those medications.
Nov 13, 2011
A 62-year-old member asked:

Why are ssri meds used so often when studies show them to be no more effective than placebos?

2 doctor answers5 doctors weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
SSRIs placebo?: Not sure where the Placebo information came from, but my experience has been that they are very effective when used for diagnosed cases and closely monitored.
A 40-year-old member asked:

What causes unhappiness and hopelessness? Just low serotonin? What foods increase serotonin?

2 doctor answers7 doctors weighed in
Dr. Steven Chen
Clinical Psychology 30 years experience
Medical vs psycholog: There are both mind and body causes of unhappiness and hopelessness. Low serotonin, hypothyroidism, and other medical conditions can impact mood. Psychologically things like loss, significant change (positive or negative) or other factors can impact mood in a negative way.
Dr. Steven Reidbord
Psychiatry 36 years experience
While I agree very much with the tone of Dr. Chen's answer, I need to add that there is no scientific evidence that "low serotonin" causes depression in humans. Many (not all) antidepressants increase serotonin's effect in the brain, but no one knows whether the serotonin itself improves mood, vs an indirect "downstream" effect. There's a lot about the brain we don't know yet.
Sep 15, 2013

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Last updated Feb 26, 2015
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