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A member asked:
How is cyproheptadine and an ssri safe to use together? don't they both affect the serotonin transmitter? but often prescribed together by docs. thx
A doctor has provided 1 answer
Serotonin antagonist: Cyproheptadine blocks receptors for serotonin, histamine, and acetylcholine. In my experience it is THE BEST treatment for akathisia. There are a handful of very old small studies suggesting antidepressant benefit. But it may worsen anxiety in some patients. It has been suggested as a way to block SSRI-induced sexual side effects. I almost never meet anyone whose doc prescribes it w/ SSRI meds.
Answered 2/26/2015
3.2k views
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