My mother have ra she is taking methotrexate and ibuprofen as analgesic are they safe together ? there is any dangerous drug-drug interaction ?!

Safe: I have seen virtually no issue in my patients who have combined these 2 meds.

Talk w her DR: about concerns . You can use a drug interaction checker whenever you have questions about drug-drug interactions or drug - food interactions. Here is 1 option (Drugs.Com): https://www.drugs.com/drug_interactions.php Your pharmacist is also a good source of info.