Maybe: The evidence that Methotrexate alone can prevent damage is not that impressive. In patients with early damage i personally prescribe combination therapy with a tnf agent and methotrexate.
Answered 6/28/2014
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Yes, sometimes: Methotrexate is a first line therapy for RA in the us and most other therapies are combined with Methotrexate unless it cannot be used. If inflammation is continuing the addition of a biologic agent (humira, enbrel, (etanercept) simponi) may help prevent longterm damage. They have been shown to provide added benefit.
Answered 1/2/2015
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