Is sertraline and hydroxyzine safe together?

Yes: No drug drug interaction.

Yes: We use this combination routinely and on daily basis in our anxiety clinic , Hydroxyzine , if it works for you is a very helpful and benign medication.

Yes: Those medications can be prescribed together

Combination is safe: It may increase dizziness, drowsiness, and difficulty concentrating, but is is a safe combination. Always talk to your doctor before combining medications.