Can taking doxycycline on an empty stomach cause me to vomit?

Yes: One of the most common side effects of most antibiotics is nausea and vomiting. Try it with food and see if it agrees with you more.

Yes: Gi side effects such as nausea, vomiting, and abdominal pain are common with doxycycline. Suggest taking it with food to see if that helps.

Yes: Doxycylline and it's cousin Erythromycin often cause GI upset (i.e. Nausea and vommiting).