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A member asked:
I have small fiber neuropathy 2nd skin biopsy shows igm deposits in vessels. also says microvascular injury syndrome. is this autoimmune process?
3 doctors weighed in across 2 answers
Complicated: There are both immune-mediated and neoplastic conditions, such as waldenstrom's macroglobulinemia and others, that can cause similar pictures. Please have an evaluation by a hematologist. Some blood tests to look for monoclonal proteins, radiologic studies, and possibly a bone marrow biopsy may be necessary to figure out what is going on. The picture needs to be put together.
Answered 5/8/2013
5.1k views
May be very complex: Small fibre neuropathy can be encountered with celiac disease, diabetes, pernicious anemia, fibromyalgia, alcohol/nutritional issues, occult neoplastic processes (as mentioned), a variety of "paraproteinemias", lupus and sjogren's disease, some of which will have immune deposits involved. Most of these situations are immune mediated and may respond to ivig. ?Visit local medical school for advice?
Answered 5/8/2013
5.1k views
Related Questions
A member asked:
I have small fiber neuropathy diagnosed by skin biopsy. I have the neuropathy in both legs, both arms, and head. I dont have diabetes or vitamin deficiencies. Would this widespread small fiber neuropathy most likely be caused by an autoimmune issue?
2 doctors weighed in across 2 answers
A member asked:
What it's mean if skin biopsy for small fiber neuropathy is normal in feet but not in hips?
A doctor has provided 1 answer
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