A member asked:

Was tested for sickle cell and the trait. i do not have either one. but i have high hemoglobin s & low a. what other than sickle cell can cause this?

6 doctors weighed in across 2 answers

Verify: I would review your results with your doctor. You indicated a high hemoglobin s and a low hemoglobin a---do you have percentages of the hemoglobins. Was a complete blood count done and results?

Answered 9/28/2016

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Dr. Craig MacArthur answered

Specializes in Pediatric Hematology and Oncology

Sickle beta thal: If you have high HGB s and low HGB a, then you have sickle beta-plus thalassemia ( if you have HGB a1), or sickle beta-zero thalassemia. ( if you have HGB a2 not HGB a1). These are both forms of sickle cell disease not trait. Beta zero is just as severe as homozygous sickle cell anemia (hgb ss); beta plus is milder in terms of symptoms.

Answered 6/10/2014

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