How does a genetic mutation cause sickle-cell disease?

Important gene...: Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease.

Dr Fowler and another doctor agreed

Abnormal protein: One genetic mutation such as the one that is found in sickle cell causes abnormal hemoglobin beta chains to form which result in sickling of the hemoglobin since it can't go to its normal shape. The sickling of the hemoglobin and red blood cell gets caught in small vessels leading to all of the problems associated with sickle cell disease.

Dr Satulovsky agreed