Which is the rate of occurrence of sickle cell disease( gene frequency, and mutation rate)?

Depends on geography: Given the single base change responsible for sickle cell trait in the beta globin gene, the frequency of new mutations is essentially zero. According to the cdc in the usa, 8-10% of african americans have sickle cell trait and 0.2% have sickle cell disease. Conversely, in western africa, the prevalence of sickle cell trait is 30-40%.

Sickle: What is the rate of occurrence for the disease sickle cell anemia or disease?" -- the occurrence rate is 25% if both parents are carriers, 50% if one parent has it and another parent is a carrier and 100% if both parents have it. Roughly 1, 000 infants are born, in the U.S., with it each year.