A member asked:

If im taking doxycycline as post exposure prophylaxis before symptoms, is it possible for a chancre to form 7 days into the treatment? im worried what i thought was a cut on my lip is the start of a chancre?

A doctor has provided 1 answer
Dr. Hunter Handsfield answered

Specializes in Infectious Disease

No. It's very unlikely a chancre could form in the week following the usual single dose of post-exposure prophylaxis with doxycycline (doxy-PEP) recommended for STI prevention in MSM (200 mg). Even without doxycycline, chancres don't form sooner than 10-12 days after exposure. Your lip cut is not a chancre.

Answered 8/24/2023

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