I had 2 reactions 3 months apart.hives in same places.both times i ate shell fish and took diflucan. pcp ran a blood panel for every type of shell fish/fish,came back negative. am i allergic to diflucan? is it possible, i have taken before many times?

Your symptom is more consistent with fixed drug eruption due to diflucan rather than allergic to shellfish. I could not rule out if shellfish or diflucan acts as a hapten or not in your case because you had no problem with taking diflucan in the past. If you need diflucan in the future, you should go ahead with close observation as a trial. Good luck.