Mirtazepine increases both norepinephrine and serotonin. Paradoxically, norepinephrine decreases melatonin and serotonin increases melatonin release. One simple method to determine if REM sleep is affected is monitoring sleep with a smart phone or smart watch. Polysomnography can accurately detail sleep disorders by measuring each sleep cycle. REM and Stage 3 are known to be "restorative sleep"
Answered 4/10/2023
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