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A member asked:
Amitriptyline vs nortripyline for gi uses and sleep?
4 doctors weighed in across 2 answers
TCA for IBS: Amitriptyline, a tricyclic anti-depressant, is in treatment of multiple conditions (eg ibs, insomnia, migraine) & not just depression. Nortriptyline is an active metabolite of amitriptyline. They may both work equally in treatment of ibs as well insomnia in the same individual. In my opinion, Amitriptyline dosing is more predictable, is more sedating & can cause more weight gain than nortripyli.
Answered 8/17/2018
5.2k views
Both are used: But amitrypiline gets my vote based on my personal experience over almost40 years and the other amount of use of this med for other uses than only depression. Nortyptilline is an ok antidepressant for the right patient.
Answered 12/11/2019
5.2k views
Related Questions
A member asked:
Amitriptyline works and stops working with each increase and I am very tired on it, after 1 week on each dose increase, from 5mg to now 20mg and i have lower abdominal burning/ibs. What medications besides nortriptyline should I ask my doctor about?
2 doctors weighed in across 2 answers
A member asked:
Why is desipramine a next recommendation instead of imipramine for functional dyspepsia when amitriptyline is too sedating and stops working and nortriptyline makes heart race?
A doctor has provided 1 answer
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