A member asked:

Is flumazenil available orally? and what is the drug similar to flumazenil?

2 doctors weighed in across 2 answers
Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

Because this drug is used to reverse the effects of a benzodiazepine and people who need this reversal effect are most likely unconscious so oral medication can't be used due to high risk of aspiration. By Drugbank online, flumazenil is the only available benzodiazepine antagonist.

Answered 10/21/2022

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Dr. Charles Turck answered

Specializes in Pharmacology

No, flumazenil is available in an intravenous (IV) form. It is used to reverse an overdose from benzodiazepines, so the IV form allows the drug to work quickly. Since most people who receive flumazenil are likely sedated or unconscious, an oral form would be difficult for the person to swallow. Flumazenil is the only drug specifically used to reverse drugs like alprazolam or lorazepam.

Answered 11/8/2022

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