Can you take a muscle relaxer when you are taking trazodone?

It depends on the muscle relaxer, but there is interaction with all of them. Physicians are advised to monitor patients on these combinations for complications. Muscle relaxers like cyclobenzaprine (Flexeril) can enhance trazodone's propensity to cause serotonin syndrome, an unpleasant hyperexcitable state. SOMA and others augment CNS depression, causing drowsiness and incoordination.