Is liquid budesodine considered off label to treat eoe?

By UPTODATE: No formulation of topical glucocorticoids has been approved specifically for EoE in the United States, while the European Medicines Agency (EMA) and Health Canada approved budesonide in an orodispersible tablet formulation for adults with EoE. Among topical glucocorticoids, fluticasone and budesonide have been best studied. Yes, off label use in the US.

Budesodine is used for Crohn's disease. It's an oral corticosteroid that, when absorbed into the bloodstream, is subject to a large first-pass effect, meaning most of it is deactivated by the liver before it reaches the general circulation. Thus, a large dose can be delivered to the GI tract without systemic complications. For the same reason, it can be used for Eosinophilic Esophagitis (EoE).