Random blood test shows ast 108 alt 283 should i be concerned with severe disease of the liver. no other symptoms?

This level in the thousand range suggests severe disease, 500's active hepatitis. The sited numbers can reflect an asymptomatic liver irritation from a transient viral infection of flu. I would repeat the test in a month or two and expect it to return to your baseline. Please discuss the values with the doc who knows your history and exam findings.