Serontinergic: Receptors do down regulate when a medication is used, they up regulate when there is no seratonin. Down regulation of Dopamine receptors does occur in cases of abuse with cocaine, high dose amphetamine , etc, not with common medications for mood. Also people may have different levels of receptors without meds, thrill seekers needing more Dopamine release to feel a charge, .
Answered 6/25/2014
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