A member asked:

Hi i have hydroxyzine hcl 25mg for anxiety i saw online it can mess with your heart rhythm is this true? im afraid to take it. ive had normal ekgs but had shown a short pr interval on i believe one of them?

2 doctors weighed in across 2 answers
Dr. Clarence Grim answered

Specializes in Endocrinology

Will depend on your other conditions & meds and family history. I would go to Drugs.com & what you want to know is in double blinded placebo controlled studies what was the incidence of "messing with heart rhythm problems" seen in those on the med & those not. Discuss with your Dr the risk/.benefit info & you will need to make the decision. Recommend uptodate.com not "online" for goo med info.

Answered 5/27/2022

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Hydroxyzrine has been shown to prolong the QT interval on an EKG increasing susceptibility to ventricular tachycardia & ventricular fibrillation and cardiac arrest. It's more dangerous when combined with certain meds that slow heart rate & also prolong the QT interval. Your short PR interval predisposes you to supraventricular tachycardias but not ventricular dysrhythmias. I think you're OK

Answered 5/28/2022

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