Will amitriptyline, ibuprofen and cafegort taken 12 hours before a urine drug test make me fail?

It should not for as long as you make known the prescribed drugs you are taking. Sometimes there are false positive results initially, but they are usually ruled out for cross reactions or confirmatory tests.

The usual tests for substances of abuse will not cause you to fail the test. You should inform the testing entity of all of your prescription medications.