TX
A 25-year-old female asked:
Can i take amitriptyline ibuprofen and flexeril (cyclobenzaprine hcl) at the same time?
2 doctor answers • 3 doctors weighed in

Dr. Andrew Germanovichanswered
Pain Management 15 years experience
It's better to take: These at separate times. Flexeril (cyclobenzaprine hcl) and amitriptyline could compound side effects if taken together. Take amitriptyline before bed.
Created for people with ongoing healthcare needs but benefits everyone.
3.7k viewsReviewed >2 years ago

Dr. Eric Weismananswered
Neurology 38 years experience
Yes: just don't take more than 600 mg of Ibuprofen every 8 hours without checking kidney function tests or if you are in the third trimester pf pregnancy. I would not take Flexeril (cyclobenzaprine hcl) for more than a few days as it can cause depression (and cognitive impairment). Don't take Elavil or any other highly anticholinergic medication if you have confusion (which you list as a condition) Otherwise go for it.
Created for people with ongoing healthcare needs but benefits everyone.
3.7k viewsReviewed >2 years ago
Last updated Mar 24, 2021
People also asked
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
24/7 visits - just $44!
50% off with $15/month membership
Disclaimer:
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.