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A 25-year-old female asked:

Can i take amitriptyline ibuprofen and flexeril (cyclobenzaprine hcl) at the same time?

2 doctor answers3 doctors weighed in
Dr. Andrew Germanovich
Pain Management 15 years experience
It's better to take: These at separate times. Flexeril (cyclobenzaprine hcl) and amitriptyline could compound side effects if taken together. Take amitriptyline before bed.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Eric Weisman
Neurology 38 years experience
Yes: just don't take more than 600 mg of Ibuprofen every 8 hours without checking kidney function tests or if you are in the third trimester pf pregnancy. I would not take Flexeril (cyclobenzaprine hcl) for more than a few days as it can cause depression (and cognitive impairment). Don't take Elavil or any other highly anticholinergic medication if you have confusion (which you list as a condition) Otherwise go for it.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Mar 24, 2021

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