A member asked:

I'm having a lot of pain in my calves. i take amitriptyline daily and wanted to know if ibuprofen is safe with it? no swelling, just throbbing pain.

A doctor has provided 1 answer
Dr. answered

Should not be an iss: Hard to say without more information and medical history. Ibuprofen and amitriptyline have no significant interactions however.

Answered 2/2/2017

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