A member asked:

Can i take vistaril with zoloft? i take 25 mg of zoloft daily, and have a prn prescription of vistaril 25 mg for insomnia and anxiety. i have been having trouble sleeping and would like to take my vistaril tonight and was wondering if this is safe?

3 doctors weighed in across 2 answers
Dr. Hunter Handsfield answered

Specializes in Infectious Disease

Google "drug interactions" to find many websites that address any potential problems between drugs. (The one I just checked, by WebMD.com, shows no interaction between these drugs.)

Answered 1/9/2022

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There should not be any incompatible drug-drug interactions, and if Zoloft does not cause drowsiness or sedation, added soporific effects of Vistaril would not be encountered. So, at doses described, appears quite safe.

Answered 1/9/2022

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