Regarding ckd with gfr between 38 to 42 ,does taking propafenone in adose of 750mg for atrial fibrillation has negative effects on renal function or causing renal damage, previously i was taking flecainide and the urea and cr was little bit lower?

I answered your previous question, propafenone can cause renal dysfunction but it is so rare that I have not seen one case in my practice. Serum creatinine and GFR fluctuate with your volume and mean arterial pressure. I only advise to stop this antiarrhythmic drug if serum creatinine increases 25% above the baseline or GFR drops 25% from the baseline, i.e. I will stop it if GFR drops below 30.