Does metformin or duloxetine cause headaches? ive been getting constant headaches for almost a yr and thinking of quitting any meds i take that could be causing it.my mri's are normal, which one would cause it and is it safe to quit taking it if need?

I strongly recommend that any withdrawal be done under the close supervision and cooperation of the prescribing doctor. Stopping a medication hopefully causes cessation of the symptom, but the risk of stopping the medication must be weighed - you will lose the positive effect as well.

Both of these medications have been reported to be associated with headache side effects, but quitting either might have adverse outcomes. Discuss a strategy with your neurologist.