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A 61-year-old male asked:

What is the recommended way to lisinopril 10mg to control bpand isosorbide mononitrate 30mg for myocardial ischemia.this combination dropped bp systolically to a very low number, make heart to race and pond. what dose adjustments is recommended?

2 doctor answers4 doctors weighed in
Dr. Hiep Le
Dr. Hiep Leanswered
Nephrology and Dialysis 44 years experience
You should take Isosorbide mononitrate in the morning and Lisinopril at dinner time. Isosorbide mononitrate is not a strong BP med so I wonder what you are feeling are the adverse effects of Isosorbide mononitrate rather than the symptoms of low blood pressure. How low is the systolic number? If systolic pressure is still less than 100 with that modification, you can cut Lisinopril tablet in half.
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I suspect the Isosorbide was responsible for the drop in the blood pressure. Was 30 mgm the starting dose? How often? What is the "very low number" for the blood pressure? I would communicate with your physician and ask for his advice. The effect of Isosorbide may also by exaggerated if you are underhydrated. Good luck.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Aug 4, 2022


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