Do not combine: Never combine lisinopril and losartan. They have similar mechanism of action and also, taken together, have more frequent side effects. Only if you have heavy proteinuria a nephrologist might give those both together. Otherwise, never combine.
Answered 3/27/2021
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ACE and ARB: I agree with D.M. In only extenuating circumstances should lisinopril and losartan be taken together. This combination of these two categories of medications put a severe strain on kidney function and can elevate serum potassium to dangerous levels.
Answered 9/4/2019
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