Do venlafaxine make you tough with people?

Possible: Mechanism of action of venlafaxine unknown. It is thought to be a reuptake inhibitor of serotonin and norepinephrine however the exact mechanism is unknown. Experience with drug and animal studies have been mixed. In some people and animals it calms and in others there has been documented aggression. I would say it would be possible the medication makes you aggressive. Let your provider know.

Venlafaxine: Hostility has been reported in 0.1 to 1 % of individuals and agitation has been reported in 1 to 10% of people taking Effexor per Drugs.Com.