Is it safe to take two extra strength tylenol 500 mg each at the same time as tramadol hcl 50 mg?

Yes: No problem with that combo

Yes, safe one time: As long as you have no liver disease, it’s safe, but make sure total amount of Tylenol you take per day is under 3,000mg (no more than 6 tablets/day) for extra strength Tylenol, and take doses ~6 hours apart. Be careful, as Tylenol (a.k.a. acetaminophen) may be included in other medications, such as medications for cough and cold or other prescription drugs – be sure to check ingredient listings.