Can a headache on top of head indicate a brain tumor?

That can be anything: Most people get a headache at some time, such as from colds, infections, lack of sleep, too much driving, long hours on the computer, stress at work, etc. Over-the-counter options include Tylenol (acetaminophen) Motrin, Alleve, Excedrin Migraine and their generic brands. A bad or increasing headache, recurrent headache, weird headache, or one that won't go away needs to be examined by a doctor.