Heartburn/indigestion, frequent urination, ankles swelling, face gets swollen, weight gain stomach area, stomach upset, upper/ lower abdominal pain, back pain, tired, stomach cramps like charlie horse. what could it be?

Many symptoms: Many symptoms but not hearing any actual diagnoses. It sounds very uncomfortable. Would start with identifying most troubling problem and work from there. Meanwhile, establishing a regular diet, water intake and exercise regimen can help. See a doctor. Focus on wellness.

Need to examine: It is nor feasible to provide a meaningful opinion without examining you and your symptoms deserve an in-person evaluation. Some of the issues may be related to menopause. It would be prudent to see your doctor.

Symptoms: The list of possible medical problems is longer than your list of symptoms. Important that you have a complete physical examination, including appropriate lab tests, as soon as possible. Please schedule appointment with your primary care provider.