Can i take trazadone 50mg and benadryl for sleep?

There are: no reasons why not....just make sure you are not drowsy in the morning...WAKE UP before you DRIVE! Hope this is helpful! Dr Z

You are on a path toward escalating sleep medication which is destined eventually to make things worse. Best not to combine if possible, and perhaps titrate the Trazadone initially without the Benadryl. Sleep hygiene program is far better, and if you can plan on stopping medication in future would provide more satisfactory patterns. An overnight sleep study would be valuable.