A 56-year-old female asked:
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how soon after completing my taper off zoloft is it safe to take tramadol without the risk of seratonin syndrome? took 100 mg for 9 months. feel fine

2 doctor answers
Dr. John Abess
47 years experience Psychiatry
1 week: The half-life of sertraline is ~ 26 hours. After completing a taper, andafter an additional 6 days, you should have negligible amounts in your system. It is good to have an awareness of the possibility of developing serotonin syndrome. But, honestly, it rarely develops to a significant degree. Many people take multiple medications with serotonin type influences and develop no signs of it.
Answered on Jan 13, 2018
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Dr. Mohammed Younus
31 years experience Psychiatry
Risk low: Risk Od serotonin syndrome with Zoloft and tramadol combination is extremely low
Answered on Jan 14, 2018
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1 thank

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Dr. Clarene Cress
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Start slow: Do you have pain that is not controlled with OTC drugs? Although SS is reported more likely with the combination of Zoloft and Tramadol, it is quite r ... Read More
A 57-year-old female asked:
Dr. Shaban Faruqui
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Not likely: Serotonin syndrome is not common
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A 22-year-old member asked:
Dr. Aruna Adaikkalam
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Very less likely.: Zoloft dose is not too high. One time of 20mg of dextromethorphan is less likely to cause seronin syndrome.

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