U.S. doctors online nowAsk doctors free
Berkeley Township, NJ
A 22-year-old member asked:

What are the chances of severe serotonin syndrome if i take two 5/325 percocets while i am on 20 mg prozac and 50 mg zoloft (sertraline)?

1 doctor answer2 doctors weighed in
Dr. Edward Kuhnley
Child Psychiatry 46 years experience
These medications:: Prozac, Percocet and Zoloft (sertraline) have a moderate degree of interactive risk including risk of serotonin syndrome when taken together. Zoloft (sertraline) and Prozac are not necessary together though your prescriber may have a reason for it. Please consult your prescriber regarding this and the mixture of medications. Best regards for relief.
Last updated Apr 20, 2016


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.