I up dosed on zoloft (for anxiety) to 150mg 8 weeks ago. i started to feel better but out of nowhere i crashed and feel bad again. anxiety, mood swings, nausea, etc. is this normal? could it be caused by not taking it the same time each day?

Unexpected.: Daily sertraline at 150 mg., after beginning to help anxiety, would be expected to continue to continue to help and not suddenly stop. There is a possibility that you need a higher dose still, or that you need different medicine. The daily time of the medicine shouldn't make much of a difference. You need to consult the prescribing doctor.