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San Antonio, TX
A 36-year-old female asked:

Why do psychiatrists start pts on lamictal & not on trileptal for bipolar? what are the main differences btw the two as theyre both anticonvulsants?

1 doctor answer1 doctor weighed in
Dr. Robert Kohn
Psychiatry 37 years experience
LTB better: Lamotrigene has been studied in bipolar 1, 2 depression and unlike Oxcarbamezapine-Trileptal, it has shown benefit. The drugs work differently, OXC blocks sodium channels and LTG additionally blocks glutamate which is an excitatory brain signal from the frontal cortex to the basal ganglia. This seems to impact mood and rumination. OXC has more use for anxiety and with juvenille bipolar clinicaly

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Last updated Aug 19, 2020

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